The QC pipeline developed by the eMERGE network has enabled a thorough analysis of the quality of the genome-wide genotype data generated on the ~17,000 samples. All of these data have been deposited in dbGaP along with corresponding quality control documents that describe all of the QC details for each dataset individually. Conducting QC in parallel at a coordinating center and study sites has been a tremendously valuable experience, as it led to a more thorough understanding since each group had to reconcile its results with others.