Chunk #17 — Results — Genome-wide analysis in the RDC schizoaffective disorder, bipolar type group v. controls

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Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept.

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Table 2Independent association signals at P<10–5 for comparison of participants in the Research Diagnostic Criteria (RDC) schizoaffective disorder, bipolar type group against controlsa Chromosome Base-pair location SNP ID Nearest genebP Supporting SNPs, n 21q22.2 39959593 rs4818065 B3GALT5 (2.9 kb) 2.32 × 10-7 1 3p21.31 49865617 rs2352974 TRAIP (0 kb) 8.27 × 10-7 3 15q26.1 87413740 rs16942644 ABHD2 (18.7 kb) 1.38 × 10-6 2 4p12 46763337 rs4279178 GABRB1 (0 kb) 2.49 × 10-6 1 5q13.3 76431673 rs13154602 FLJ18221 (0 kb) 2.99 × 10-6 4 16p13.3 6072788 rs4786811 A2BP1 (0 kb kb) 3.71 × 10-6 1 13q14 42297245 rs7990962 C13orf30 (33.6 kb) 5.61 × 10-6 4 2p25.1 11954943 rs4027132 LPIN1 (70 kb) 6.63 × 10-6 0 4p12 46839864 rs7680321 GABRB1 (0 kb) 7.28 × 10-6 3 6q14.2 84286342 rs1171115 PRSS35 (0 kb) 8.36 × 10-6 3 SNP, single nucleotide polymorphism; ID, identification. a. ‘Independent’ is defined as linkage disequilibrium r2<0.2. Physical location is given as base-pair location on the chromosome according to genome build 126. The P is the significance of the λ-corrected Cochran—Armitage trend test. The supporting SNPs have P<0.001, lie