To date, only one study has examined the potential mediating role of parental closeness on the relationship between parental and adolescent substance use, finding no evidence for mediation (Zhang et al., 1999). No study has examined both parental closeness and monitoring as mediators of the relationship between parental and adolescent substance use within the same predictive model. Such a model has the potential to advance our knowledge of the significance of each variable relative to the other, and may have implications for more targeted parent- or family-based intervention programs.