2005). Zink et al. (2009) demonstrated similar reductions in complexin II mRNA in mPFC of young (postnatal day (PD) 8) rats exposed to ethanol from gestational day (GD) 1 to PD 8 via housing in an inhalation chamber. Given that Complexin II is localized to axospinal and axodendritic synapses (Yamada et al., 1999), these findings imply that ethanol exposure during development induced a reduction in synapses.
