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Chunk #28 — Discussion — Drug - gene interactions

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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.
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Further, our work highlights other potential druggable genes associated with depression which are not, to our knowledge, currently associated with antidepressant treatment or mood-associated adverse effects. These include the R-type calcium channel gene, Calcium Voltage-Gated Channel Subunit Alpha1 E (CACNA1E), and the nucleosome associated gene, Lysine Methyltransferase 2A (KMT2A).