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Chunk #52 — ONLINE METHODS — Secondary analyses in core PGC dataset — Summary-data-based Mendelian Randomization (SMR) analysis, FUSION and EpiXcan

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Mapping genomic loci implicates genes and synaptic biology in schizophrenia.
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regions due to the complexity of this region. For blood, we included only genes with eQTLs in brain. This left 7,803 genes in blood, 10,890 genes in prefrontal cortex and 754 genes in fetal brain for analysis (see Supplementary Note for further details). SMR was performed using data from the primary GWAS. The results were then filtered to exclude significant SMR implicated genes where the eQTLs did not map within our definition of an associated locus in the Extended GWAS meta-analysis of our primary GWAS dataset and the dataset provided by deCODE genetics.