A series of models using a pooled sample were conducted to assess whether the association of genotype and GxE interactions with alcohol dependence varied by gender. The first set of models examined genotype by gender interactions. Model 1 included only genotype; Model II added gender and control variables; and Model III added an interaction term for gender*genotype. The second set of models examined interactions between genotype and daily hassles and uplifts. Model I included genotype, gender, daily hassles, daily uplifts, and control variables; Model II added a two-way interaction term for genotype*uplifts; and Model III added a three-way interaction term for genotype*gender* uplifts. The three-way interaction model tested whether GxE effects differed by gender. Two additional models (not shown) included a two-way interaction term for genotype*hassles and a three-way interaction term for genotype*gender*hassles. Because there was no evidence of a GxE or GxExE effect of the hassles scale, these findings were reported in text, but not in tables or figures.
