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Chunk #34 — Results — Validation of oligodendrocyte pathology in Parkinson’s disease

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Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease.
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Third, we tested whether genes with rare variants associated with Parkinsonism (Table S12) were specifically expressed in cell types from the mouse nervous system (Method). As for the common variant, we found the strongest enrichment for cholinergic and monoaminergic neurons (Table S13). However, we did not observe any significant enrichments for oligodendrocytes or enteric neurons using genes associated with rare variants in Parkinsonism.