Chunk #13 — Results — Main effect of the 5-HTTLPR polymorphism on current depressive symptoms

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Financial difficulties but not other types of recent negative life events show strong interactions with 5-HTTLPR genotype in the development of depressive symptoms.

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Main effect of the polymorphism was only detectable in the population sample of Budapest (896 subjects), using additive (P=0.0497) and recessive (P=0.0133) models. After calculating for FDRs with the QVALUE programme, the significant main effect of 5-HTTLPR in the additive and recessive models no longer met the significance criteria (Tables 2, 3, 4).