No significant enrichment of genes associated with either of the seven glycemic traits tested was observed for the set of nuclear regulators of mitochondrial genes, the OXPHOS genes or the full set of nuclear-encoded mitochondrial genes, after correcting for multiple hypothesis testing (Table 4). Similar results were obtained between all three gene sets and T2D or the seven glycemic traits tested, using an alternative GSEA statistical test based on a rank-sum test (see Materials and Methods and Table S13) or using an alternative gene score correction method (modified Sidak's correction; Table S14), confirming the robustness of these results.
