Chunk #17 — Results — Replication in Atherosclerosis Risk in Communities (ARIC) Study

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Hemizygous Deletion on Chromosome 3p26.1 Is Associated with Heavy Smoking among African American Subjects in the COPDGene Study.

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While we were not able to replicate this result in the ARIC study, a SNP (rs6762258) on chromosome 3 in GRM7 was marginally associated with the log10(pack-years) adjusting for age, gender, and genetic ancestry via PCAs (p = 0.004) among AA in the COPDGene study. This SNP (rs6762258) showed almost no correlation with the CNV component of interest (correlation coefficient = 0.04; p = 0.03).