three additional participants from the Knight-ADRC study with PSEN1 (A79V, I143T, S170F) mutations. Clinical Dementia Rating (CDR) scores were obtained during regular visits throughout the study before the subject’s decease [36]. A range of other pathological measurements were collected during autopsy including Braak staging, as previously described [37].Table 1Demographics and disease status of cohorts from four brain bank resourcesMayoMSBBDIANKnight-ADRCSample size19130019103Age (years)83 ± 7.7783.3 ± 7.5550.6 ± 7.0685.1 ± 9.78Male (%)45.53668.438.8APOE ε4+ (%)33.231.714.345.6Brain weight––1187.7 ± 184.51138.1 ± 142.5AD821351987PA29000Control8085016CDR = 0–40013CDR = 0.5–4009CDR = 1–30211CDR = 2–44414CDR = 3–146156Mayo Mayo Clinic, MSBB Mount Sinai Brain Bank, AD Alzheimer’s disease, PA pathological aging, CDR Clinical Dementia Rating for available samples
