Chromosomes 5 (11 and 21 genes for the ACB-shell and CeA, respectively) and 6 (10 and 18 genes for the ACB-sh and CeA, respectively) had the most genes that were significantly different between the ethanol and water groups and were located within a rat ethanol preference QTL (Bice et al., 1998; Carr et al., 1998, 2003; Foroud et al., 2003). There were no genes in common within these QTLs that differed between the ethanol and water groups in both regions, suggesting regional differences in mRNA regulation is influencing the effects of chronic alcohol drinking.
