SNP selection was conducted in two rounds. These 190 candidate genes were processed by TAMAL v2.0 [Hemminger et al., 2006], indicating that 186 could be uniquely mapped. SNPs were selected to tag common variation in Europeans (using TAGGER, aggressive tagging, r2 threshold 0.8, and any coding SNPs forced in). Additional SNPs with MAF ≥0.05 in splice sites, exons (synonymous or non-synonymous), and highly conserved regions were selected along with SNPs in predicted promoter, regulatory, transcription factor binding, and micro RNA target sites. The final list comprised 186 genes and 6,568 SNPs and was sent to Illumina for genotyping with their Custom Infinium Genotyping Beadchips platform.
