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Chunk #25 — Results — Phenotypic associations — Ext, INT, and EF predicting alcohol transitions — Internalizing.

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Alcohol milestones and internalizing, externalizing, and executive function: longitudinal and polygenic score associations.
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INT was not significantly associated with hazards for any alcohol transitions (HR = 0.82–1.18, p ⩾ 0.043, pFDR ⩾ 0.53; Figure 1a; online Supplementary Table S1). However, post hoc analyses revealed that social anxiety symptoms and suicidal ideation were significantly associated with increased hazards for progression from first drink to first severe AUD (online Supplementary Fig. 1; Supplementary Table S2).