As an initial analysis to guide the multivariate analyses, we performed hierarchical clustering of a matrix with pair-wise LD Score (version 1.0.0) genetic correlations (rg) (Supplementary Information section 3). The 11 phenotypes displayed appreciable genetic overlap with at least one other phenotype (max |rg| = 0.245–0.773) (Supplementary Table 5). Three (k) clusters were identified: (1) attention deficit/hyperactivity disorder (ADHD), educational attainment (EDUC), age at first sexual intercourse (FSEX), irritability (IRRT), and smoking initiation (SMOK); (2) problematic alcohol use (ALCP), drinks per week (DRIN); and (3) lifetime cannabis use (CANN), automobile speeding propensity (DRIV), number of sexual partners (NSEX), general risk tolerance (RISK).
