RNase MRP complex)69. In the context of our model, this report is intriguing because the RNase MRP complex is involved in diverse cellular and mitochondrial functions; moreover, patients with mutations in RMRP develop cartilage–hair hypoplasia syndrome that is characterized by premature multi-organ failure mainly in highly proliferative organs, consistent with possible stem-cell failure. Thus, there is a growing appreciation that the activities of TERT beyond telomere maintenance may affect age-relevant processes linked to optimal mitochondrial and stem-cell function.
