The following genotype frequencies were observed for rs1391166: AA (n = 31), AT (n = 66), and TT (n = 15). For rs1497571, the observed genotype frequencies were: CC (n = 33), CT (n = 71), and TT (n = 18). The first SNP, rs1391166, is located in intron 1 and the estimated heterozygosity according to publicly available databases (http://www.ncbi.nlm.nih.gov/projects/SNP/) is 0.49 (SE = 0.065), while the observed heterozygosity in this sample was 0.59. The second SNP, rs1497571 is located in intron 7 with expected heterozygosity of 0.50 (SE = 0.036) and observed was 0.58. These departures were approximately within 2 SE of the mean. Data available on the SNP database using HapMap samples indicated that allele frequencies for both SNPs differ by ethnicity, such that the major allele was less frequent in individuals of Asian descent compared with individuals of European or African ancestry. For both alleles, tests for conformity to Hardy–Weinberg Equilibrium indicated departure from expected values, χ2(1) = 4.62, p = 0.032 for rs1391166 and χ2(l) = 4.03, p= 0.045 for rs1497571.
