The integration of mapping cis- and transacting loci for specific cellular contexts with comparable data sets defining transcription factor binding, chromatin accessibility, and DNA looping across the genome (30) is a key step in resolving the functional genomic landscape on an individual basis. This study demonstrates the importance of considering the cellular context, and by extension a myriad of other stimuli and the developmental state, in the continued effort to understand the nature and functional consequences of genetic variation and translate this into patient benefit through individualized therapy and more rational drug design.
