Figure 3d illustrates another novel psychiatric risk locus associated with SCZ, BIP, ASD, and OCD (Pmeta = 3.58 × 10−8). The lead SNP rs10265001 resides between MRPS33 (Mitochondrial Ribosomal Protein S33) and BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase) on 7q34. The brain Hi-C data indicated interaction of the associated region with the promoters of two nearby genes: BRAF, which contributes to the MAP kinase signal transduction pathway and plays a role in postsynaptic responses of hippocampal neurons (Grantyn and Grantyn, 1973), and KDM7A (encoding Lysine Demethylase 7A), which plays a central role in the nervous system and midbrain development (Horton et al., 2010; Qi et al., 2010; Tsukada et al., 2010).
