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Chunk #0 — 1. Introduction

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Random Forest Classification of Alcohol Use Disorder Using fMRI Functional Connectivity, Neuropsychological Functioning, and Impulsivity Measures.
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Alcohol use disorder (AUD) is a chronic, addictive, and relapsing disorder [1,2]. Individuals with chronic AUD manifest a variety of neurocognitive impairments [3], which may underlie both structural and functional features of the brain [4,5,6], and some of these impairments do not recover even after prolonged abstinence from drinking [7,8]. Recent studies have proposed the potential utility of resting state functional Magnetic Resonance Imaging (fMRI) connectivity as one of the neuroimaging biomarker for the quantitative clinical evaluation of AUD [9,10,11]. Therefore, it may be important to further confirm the utility of this neural measure as a potential biomarker, which can be used to improve the predictive accuracy of AUD diagnosis [11,12,13].