The notion put forward here is that when regulatory elements occur within a GRB, which is the case for FTO/IRX3/IRX5, it is likely that they target the anchor gene (IRX3/IRX5), given its importance. Supplemental Table 5 contains an annotation of GRBs and their anchor genes and the GWAS SNPs within the GRB as well as annotation regarding whether the nearest gene is the anchor gene or not. In those cases in which the nearest gene differs from the anchor gene, we propose that the anchor gene be used as the putative target and additional experimentation as shown in this work should be performed to precisely determine which is the target gene for the GWAS-affected regulatory element.
