We began by examining whether polygenic variation related to externalizing predicted disturbances in functional network connectivity. The externalizing PS was associated with hyper-connectivity in a network centered on left amygdala (10 nodes, 9 links, corrected p =.046). As displayed in Figure 1, this network encompassed cortical (bilateral inferior frontal gyrus [IFG] pars triangularis and left rostral anterior cingulate cortex [ACC]) and subcortical regions (bilateral amygdala, hippocampus, and striatal areas) that have been implicated in emotion regulation and inhibitory control. The externalizing PS accounted for significance variance (ps<.005) in the strength of connectivity in this resting-state network across multiple significance p-value thresholds (see Table 2).
