also found inhibition-related activation in frontostriatal circuits to be highly correlated (positively) with D2/D3 receptor availability. Reductions in inhibition-related frontal activation have been reported in those with PTSD (Falconer et al., 2008). Consistent with these reports, Hamidovic et al.’s (2009) findings suggest that the rs12364283 G allele, while associated with better response inhibition and lower impulsivity at baseline, increases carriers’ sensitivity to amphetamine’s effects on inhibitory control and perhaps PTSD liability. The findings in amphetamine dependent individuals in our sample, which do not appear to be primarily mediated via impulsivity, may thus be viewed as the results of a naturalistic experiment that could provide insight into the pathophysiology of PTSD.
