across a wide range of paradigms [34]. Although CRH-BP deficient mice have normal baseline and stress-exposed HPA axis function they show increased anxiety-like behavior indicating an important role for CRH-BP in the CNS extra-hypothalamic stress response system [35]. CRH-BP located in the ventral tegmental area (VTA) has been shown to modulate the effects of CRH on stress-induced relapse to drug abuse [36]. Thus CRH-BP is a logical candidate gene for anxiety and addiction.
