Chunk #35 — Background — Description of clinical characteristics of KPD and how the family data were collected and classified

Source

Construction of the model for the Genetic Analysis Workshop 14 simulated data: genotype-phenotype relationships, gene interaction, linkage, association, disequilibrium, and ascertainment effects for a complex phenotype.

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The frequency of KPD is difficult to estimate, given the ambiguous nature of its symptoms. It has been estimated to occur in as much as 10% of the population, although it appears common in some areas but absent in others. Also, diagnostic criteria vary. The best estimate is that the population prevalence is 3%.