the over correction of inflated false positive rates. Another concern in estimating relatedness is potential violation of the HWE assumption which might affect the resulting MLEs if there is Hardy-Weinberg Disequilibrium (HWD) in the sample. We have not formally evaluated the effect of HWD on the resulting estimates. Since substantial HWD is rare in unstructured populations and inbreeding (leading to HWD) levels are small even in genetic isolates that have been evaluated [Agarwala et al., 2001], it is likely that the impact of HWD is minimal.
