In summary, while these simulations include exaggerated patterns of enrichment (e.g., 100% of heritability in DHS flanking regions), the results highlight the possibility that two-category estimators of enrichment can yield incorrect conclusions. Although we cannot entirely rule out model misspecification as a source of bias for stratified LD score regression with the full baseline model, we have shown here that it is robust to a wide variety of patterns of enrichment, because including many categories gives it the flexibility to adapt to the unknown causal model.
