Exploratory analyses examining whether polygenic risk for ‘problematic alcohol use’ and/or low alpha EEG interhemispheric coherence moderate the associations of the COVID-19 factors and changes in drunkenness are presented in Supplementary Table 3. Exploratory analyses indicated that associations between family illness or death with increases in drunkenness and increased relationship quality with decreases in drunkenness were more pronounced among the remitted-drinking participants with higher PRS. Associations between family illness or death, media consumption, and economic hardships with increases in drunkenness and healthy coping with decreases in drunkenness were more pronounced among the remitted-abstinent group with lower interhemispheric alpha EEG connectivity. No main effects of PRS or neural connectivity on COVID-19 drinking outcomes were observed.
