times higher catalytic activity than the normal enzyme. Increased accumulation of acetaldehyde from due to higher catalytic activity of “atypical ADH” is responsible for the flushing and severe symptoms of alcohol related sensitivity[37, 40]. The intense aversive reaction to even smaller amounts of alcohol deter individuals from consuming large amounts of alcohol and protects them from developing AUD[36, 37, 40, 42]. Indeed, the His48 allele was also found to be associated with lower alcohol consumption as measured by the subjects’ lifetime maximum alcohol consumption in a 24-hour period (β = −0.28 (95% CI −0.35, − 0.20), p value = 3.24 × 10−13)[36].
