Clinical Interview for Axis I DSM-IV Disorders – Patient Edition: SCID-I/P, version 2.0) [58], and the 17-item Hamilton Depression Rating Scale (HamD17) [59]. Depressed subjects had HamD17 scores ≥16 at entry. Exclusion criteria included psychotic symptoms, cluster A or B Axis II disorders, prior suicidal ideation, or any serious medical conditions known to affect brain function or to contraindicate use of the active medication. Subjects were free of psychotropic medications for at least two weeks prior to enrollment. There was no significant difference in the mean age or gender or handedness ratios between the two subject groups, although predictably, the MDD subjects had significantly higher mean HamD17 score than did control subjects (Table 1).