In conclusion, our study prioritizes risk variants and genes for subsequent experimental follow-up, which will help interrogate the molecular mechanisms underlying the link between alcohol consumption and AUD. Our database of multi-omics analysis in the fetal and adult brain is also made available with this study (see URLs) and provides a starting point to elucidate the biological mechanisms underlying AUD. We have demonstrated that individuals susceptible to AUD may have altered expression of disease-causing genes at earlier stages of life. Moreover, our results show the pleiotropic role of AUD-related variants in a variety of other brain disorders including Alzheimer’s disease. We expect results of multi-omic integration analysis will help researchers to design genetically informed experiments to identify biological mechanisms and drug targets related to AUD.
