Chunk #28 — Simple combinations of binding sites identify cell type-specific repertoires of H3K4me1-marked regions

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Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities.

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nucleosome distribution observed when aligning the data on the means of the tag distributions (Figure S4F) and establishes that the central gap in the H3K4me1 pattern over the transcription factor motif is reflective of the absolute nucleosome positions and represents the predominant DNase Iaccessible location at these promoter-distal sites.