Chunk #1 — Background

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Characterizing and measuring bias in sequence data.

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yes

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Our goal in this work was to develop a rigorous method for discovering and monitoring coverage and error biases, then to apply it to data from a wide range of sequencing platforms (Illumina HiSeq and MiSeq, Ion Torrent PGM, Pacific Biosciences RS, and the Complete Genomics sequencing service). This study complements previous work in the field [3-7].