Data on trauma exposure was available for analysis on 6613 EA individuals. Lifetime trauma exposure was reported by 12.8% of the sample. Note, trauma exposure was reported by 12.3% of those assessed with the SSAGA-IV (full trauma checklist, Supplementary Table 3) and 15.4% of those assessed with an earlier SSAGA (abbreviated, as described above). Trauma exposure was associated with cannabis use (B: 0.065, p < 0.017, R2: 0.004) and DSM-5 CUDsx (B: 0.161, p < 0.0001, R2: 0.026); trauma exposure was more common in cannabis users (12.9%) compared with non-users (7.6%) and in those meeting criteria for DSM-5 CUD (15.8%). Trauma exposure also moderated the association of the PRS (p < 0.05 threshold) with cannabis ever use in both Model 1, which adjusted for age, sex, birth cohort, genotype array, and genetic ancestry, and Model 2, which also included two-way interactions for all variables included in the model (Table 3). Interactions among trauma exposure and PRS with p < 0.05 and p < 0.10 thresholds were observed for cannabis ever use but not DSM-5 CUDsx (Table 3). Both PRS had
