Chunk #60 — Discussion

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Adolescent binge drinking alters adult brain neurotransmitter gene expression, behavior, brain regional volumes, and neurochemistry in mice.

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In summary, adolescent binge ethanol treatment of mice reduces young adult neurotransmitter gene expression, particularly cholinergic genes, as well as forebrain MRI volume, histologic area, cholinergic neuron immunohistochemistry, and reversal learning performance.