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Chunk #32 — Materials and Methods — Resting state scans — Analysis

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The hippocampus is coupled with the default network during memory retrieval but not during memory encoding.
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For the resting state coherence analysis, we used the Group ICA fMRI toolbox (GIFT v2.1, http://software.incf.org/software/group-ica-toolbox-gift-and-eegift/home) developed by Calhoun and colleagues [49]. We entered subjects and the two rest runs as experimental factors and used all the default settings of the GIFT software (20 components, Infomax algorithm). Next, we averaged the two runs for each subject, and subsequently used SPM5 to conduct a random effects analysis on the resulting coherence maps. Regions were classified as significant when they exceeded an FDR-corrected threshold of p<0.005, and a cluster extent threshold of 25 voxels.