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Chunk #27 — DISCUSSION

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Peroxisome proliferator-activated receptors α and γ are linked with alcohol consumption in mice and withdrawal and dependence in humans.
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induced changes in the expression of immune-related genes in the liver but did not produce prominent changes in neuroimmune pathways in C57BL/6J mice (Ferguson et al., 2014). NF-κB targets were not downregulated in liver or brain following PPAR agonist treatment, but it should be noted that these mice were ethanol naive (Ferguson et al., 2014).