Expression quantitative loci were examined in two independent data sets: the NABEC (GSE36192)24 and UKBEC (GSE46706)44,45. Detailed processing and exclusion criteria for both data sets are described elsewhere24,45. In brief, the UKBEC consists of 134 neuropathologically normal donors from the MRC Sudden Death Brain Bank in Edinburgh and Sun Health Research Institute; expression was profiled on the Affymetrix Exon 1.0 ST array. The NABEC is comprised of 304 neurologically normal donors from the National Institute of Ageing and expression profiled on the Illumina HT12v3 array. The expression values were corrected for gender and batch effects and probes that contained polymorphisms (seen > 1% in European 1000G) were excluded from analyses44. Blood expression quantitative trait loci (eQTL) data were queried using the Blood eQTL Browser (http://genenetwork.nl/bloodeqtlbrowser/)26. Brain expression over the lifespan was measured from a spatio-temporal atlas of human gene expression and graphed using custom R scripts (GSE25219; details given in13).
