expression was seen amongst colon cancer samples, but not observed in normal colon from the same patients, implying that the impact of the variant is dependent on disease-specific environmental factors [80]. The effect of noncoding variants on expression was also observed to be strongly context dependent in a study of monocytes under diverse types and durations of stimuli. Fairfax and colleagues demonstrated that 43% of identified eQTLs were associated with an effect on expression only after treatment with immune response stimuli lipopolysaccharide or interferon-γ [81].
