Linear regression analyses indicated an interaction of ALDH2 and ADH1B in their association with total symptoms and SRE_5. For total symptoms, the ALDH2-ADH1B interaction term entered in step 2 was significant (F change = 8.05, p = .005). For SRE_5, the interaction approached significance (F change = 3.25, p = .072). Because the ALDH2-ADH1B interaction terms reached or approached significance for both of these variables, we next stratified the data by ALDH2 genotype and tested for mean differences in total symptoms and SRE_5 across ADH1B genotype.
