p-values did not meet significance. Although we did not detect an association with CHRNB2 in this study, only four SNPs (not including rs2072658) were genotyped, so it is possible this gene was not fully saturated. Since α4 and β2 subunits combine to form the most abundant high affinity nAChRs in the brain, and two separate studies have implicated these genes in early subjective response to nicotine, we believe additional work examining CHRNA4 and CHRNB2 with related subjective effects measures is merited.
