In the pallium, Zfhx1b functions in both progenitors and neurons. In hippocampal progenitors, it functions upstream of Wnt signaling to control development of the entire region (Miquelajauregui et al., 2007). In neocortical neurons Zfhx1b regulates neurotrophin-3 and Fgf9 expression, to control cortical progenitors (Seuntjens et al., 2009). We did not observe similar regulatory changes in the Zfhx1b mutant MGE.
