recent study some of these genetic targets including ADH1B, GCKR, SLC39A8 and KLB have been shown to play a conserved role in phenotypic responses to alcohol in Caenorhabditis elegans [74]. Researchers are also using the post-mortem brain tissue from alcoholic subjects to understand the effect of long-term alcohol consumption on expression of genes. Recently, Kapoor and colleagues[73] have suggested that genes identified in alcohol related GWASs (AD and alcohol consumption) interact with genes affected by alcohol exposure and results in system wide changes across pathways and networks involved in alcoholism. Better understanding of these pathways will definitely result in better therapeutic interventions for AUD and problematic drinking[73].
