Chunk #13 — Methods — Genotype Imputation

Source

In search of rare variants: preliminary results from whole genome sequencing of 1,325 individuals with psychophysiological endophenotypes.

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For all single variant association analyses, we used the full set of 27 million imputed SNPs. For gene-based burden tests, we restricted the set of imputed variants to those imputed with sufficient accuracy, as judged by an imputation minimac RSQ > .3 (Li et al., 2010).