The SNP of interest is rs16969968. However, the most frequently genotyped tag SNP for rs16969968 is rs1051730, which has an r2= 1.00 with rs16969968 based on the CEU 1000 Genomes sample.29,30 Therefore, rs1051730 was used in analyses when rs16969968 was unavailable. We report the results as an association with rs16969968 because (1) they are statistically equivalent results and (2) there is biological evidence that rs16969968 alters receptor function.21 The minor allele frequency for each sample in the meta-analysis is given in the Table.
