Genes shared between BIP and cannabis phenotypes were enriched for drug targets of duloxetine, an antidepressant52 and reliever of chronic pain.53 Medicinal cannabis use has been linked to both lower self-reported depression54 and pain management.55 Although cannabis use/misuse is also associated with adverse effects, including higher risk of depression, suicidal behaviors,56 and worse analgesic outcomes.57 Further investigation is required to explore this potential biological mechanisms linked to cannabis, antidepressants, and analgesics. Taken together, the mixed effect directions and the gene-drug interactions help explain the mixed relationship between cannabis use and symptom dimensions in psychotic disorders.
