and 50 in other domains (13 medical, 33 psychiatric [9 PTSD, 11 depression, 7 antisocial personality, 3 suicide, 2 ADHD, and 2 conduct disorder], 9 environmental, and 6 demographic phenotypes. Again, compared to FTND PGS, TUD-EUR PGS was more strongly associated across virtually all domains, including nicotine dependence (Nagelkerke’s R2=0.101 vs 0.062; Supplementary Table 36). After conditioning on PGS for other smoking variables (CPD, SmkInit, FTND), TUD PGS was still significantly associated with 11 smoking-related traits and 50 other mental and medical conditions (Supplementary Table 36), again emphasizing the value of collecting information on later stages of vulnerability or more severe phenotypes, such as TUD.
