Tissue and cell type enrichment analysis revealed significant enrichment of OCD SNP heritability in several tissues and cell types, with the strongest enrichment in excitatory neurons of the hippocampus and the cerebral cortex and in dopamine D1 receptor (D1R)-positive and dopamine D2 receptor (D2R)-positive MSNs in the striatum. These findings are in line with traditional neural circuitry models of OCD, which focus on frontal cortical–striatal pathways68,69. These findings are consistent with and build on previous work linking various neuronal cell types to psychiatric and cognitive phenotypes70.
