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Chunk #43 — Discussion

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Increased intra-participant variability in children with autistic spectrum disorders: evidence from single-trial analysis of evoked EEG.
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These data suggest that previous reports of increased response time variability in those with ASD (Geurts et al., 2008) may be underpinned by variability within cortical dynamics associated with the ability to synchronize the activity of stimulus-related cell assembly(ies) consistently across trials. The experimental paradigm used here did not elicit a significant difference between response time variability in those with and without ASD. This may be because only a small number of trials (36) were available to ascertain variability, in contrast to Geurts et al. (2008) who used nearly twice as many (64 trials), or it may be because of the small group sizes and consequently reduced power of the analyses performed here. Nevertheless, there was a significant relationship between response time variability and P1 amplitude variability. Note that P1 and the behavioral data were extracted from separate trials (the P1 was extracted from trials in which the eliciting stimulus was a Gabor patch with a spatial frequency content of 8 cycles/degree and the behavioral data were derived from trials in which the eliciting stimulus was a zebra), therefore it